| # | Player | G | Passing TDs |
|---|---|---|---|
| 1 | Dak Prescott DAL | 12 | 26 |
| 2 | Josh Allen BUF | 13 | 25 |
| 3 | Tua Tagovailoa MIA | 12 | 24 |
| 4 | Brock Purdy SF | 12 | 23 |
| – | Patrick Mahomes KC | 13 | 23 |
| 6 | Jordan Love GB | 12 | 22 |
| 7 | Russell Wilson DEN | 12 | 21 |
| 8 | Jared Goff DET | 12 | 20 |
| – | C.J. Stroud HOU | 12 | 20 |
| – | Justin Herbert LAC | 12 | 20 |
| 11 | Jalen Hurts PHI | 12 | 19 |
| 12 | Kirk Cousins MIN | 8 | 18 |
| – | Baker Mayfield TB | 12 | 18 |
| – | Sam Howell WSH | 13 | 18 |
| 15 | Matthew Stafford LAR | 11 | 16 |
| 16 | Geno Smith SEA | 12 | 15 |
| – | Joe Burrow CIN | 10 | 15 |
| 18 | Trevor Lawrence JAX | 12 | 14 |
| 19 | Lamar Jackson BAL | 12 | 13 |
| 20 | Justin Fields CHI | 8 | 12 |
| 21 | Derek Carr NO | 12 | 11 |
| 22 | Mac Jones NE | 11 | 10 |
| – | Gardner Minshew IND | 11 | 10 |
| 24 | Bryce Young CAR | 11 | 9 |
| 25 | Joshua Dobbs ARI | 8 | 8 |
| – | Desmond Ridder ATL | 11 | 8 |
| 27 | Jimmy Garoppolo LV | 6 | 7 |
| – | Tommy DeVito NYG | 5 | 7 |
| – | Will Levis TEN | 6 | 7 |
| – | Deshaun Watson CLE | 6 | 7 |
| 31 | Zach Wilson NYJ | 10 | 6 |
| – | Kenny Pickett PIT | 12 | 6 |
| 33 | Joshua Dobbs MIN | 4 | 5 |
| 34 | Aidan O'Connell LV | 6 | 4 |
| 35 | Bailey Zappe NE | 6 | 3 |
| – | Taylor Heinicke ATL | 3 | 3 |
| – | Tyson Bagent CHI | 5 | 3 |
| – | Mitchell Trubisky PIT | 4 | 3 |
| – | Jake Browning CIN | 4 | 3 |
| – | Anthony Richardson IND | 4 | 3 |
| – | Kyler Murray ARI | 4 | 3 |
| 42 | Joe Flacco CLE | 1 | 2 |
| – | Tyrod Taylor NYG | 6 | 2 |
| – | Andy Dalton CAR | 2 | 2 |
| – | Daniel Jones NYG | 6 | 2 |
| – | Jameis Winston NO | 5 | 2 |
| – | Ryan Tannehill TEN | 6 | 2 |
| 48 | PJ Walker CLE | 5 | 1 |
| – | Devin Singletary HOU | 11 | 1 |
| – | Mike White MIA | 4 | 1 |
| – | Tyler Huntley BAL | 3 | 1 |
| – | Keenan Allen LAC | 12 | 1 |
| – | Dorian Thompson-Robinson CLE | 4 | 1 |
| – | Tim Boyle NYJ | 3 | 1 |
| – | Taysom Hill NO | 12 | 1 |
| – | Derrick Henry TEN | 12 | 1 |