| # | Player | G | Rushing TDs |
|---|---|---|---|
| 1 | Josh Allen BUF | 3 | 6 |
| – | Derrick Henry BAL | 3 | 6 |
| 3 | Jonathan Taylor IND | 3 | 4 |
| – | Jahmyr Gibbs DET | 3 | 4 |
| 5 | D'Andre Swift CHI | 3 | 3 |
| – | Christian McCaffrey SF | 3 | 3 |
| 7 | David Montgomery HOU | 3 | 2 |
| – | Javonte Williams DAL | 3 | 2 |
| – | Kenneth Walker III KC | 3 | 2 |
| – | Cam Ward TEN | 3 | 2 |
| – | Bhayshul Tuten JAX | 3 | 2 |
| – | Bijan Robinson ATL | 3 | 2 |
| – | Omarion Hampton LAC | 3 | 2 |
| – | Caleb Williams CHI | 2 | 2 |
| – | James Cook III BUF | 3 | 2 |
| 16 | Lamar Jackson BAL | 3 | 1 |
| – | Jonah Coleman DEN | 1 | 1 |
| – | Ollie Gordon II MIA | 2 | 1 |
| – | Jacoby Brissett ARI | 3 | 1 |
| – | Brian Robinson Jr. ATL | 3 | 1 |
| – | Kyle Monangai CHI | 3 | 1 |
| – | Cam Skattebo NYG | 3 | 1 |
| – | Mike Washington Jr. LV | 3 | 1 |
| – | Breece Hall NYJ | 3 | 1 |
| – | Malik Willis MIA | 3 | 1 |
| – | Jacory Croskey-Merritt WSH | 3 | 1 |
| – | Chris Rodriguez Jr. JAX | 3 | 1 |
| – | TreVeyon Henderson NE | 2 | 1 |
| – | Baker Mayfield TB | 3 | 1 |
| – | Braelon Allen NYJ | 3 | 1 |
| – | Tyler Shough NO | 3 | 1 |
| – | Bucky Irving TB | 3 | 1 |
| – | Woody Marks HOU | 3 | 1 |
| – | Jalen Hurts PHI | 3 | 1 |
| – | AJ Barner SEA | 3 | 1 |
| – | Jeremiyah Love ARI | 3 | 1 |
| – | Patrick Mahomes KC | 3 | 1 |
| – | Tank Bigsby PHI | 3 | 1 |
| – | Chuba Hubbard CAR | 3 | 1 |
| – | Aaron Jones Sr. MIN | 3 | 1 |
| – | Kendre Miller NO | 2 | 1 |
| – | KaVontae Turpin DAL | 3 | 1 |
| – | Jordan Mason MIN | 1 | 1 |
| – | Case Keenum CHI | 1 | 1 |
| – | Brock Purdy SF | 3 | 1 |
| – | Bo Nix DEN | 3 | 1 |
| – | Kyren Williams LAR | 3 | 1 |
| – | Kenyon Sadiq NYJ | 3 | 1 |
| – | Bryce Young CAR | 3 | 1 |
| – | Chase Brown CIN | 3 | 1 |