| # | Player | G | Home Runs |
|---|---|---|---|
| 1 | Cal Raleigh SEA | 174 | 67 |
| 2 | Shohei Ohtani LAD | 176 | 62 |
| 3 | Kyle Schwarber PHI | 167 | 57 |
| 4 | Aaron Judge NYY | 162 | 55 |
| 5 | Junior Caminero TB | 157 | 46 |
| 6 | Juan Soto NYM | 160 | 43 |
| 7 | Pete Alonso NYM | 164 | 39 |
| 8 | Michael Busch CHC | 163 | 38 |
| – | Taylor Ward LAA | 162 | 38 |
| – | Julio Rodriguez SEA | 176 | 38 |
| – | Jo Adell LAA | 156 | 38 |
| 12 | Seiya Suzuki CHC | 159 | 37 |
| – | Byron Buxton MIN | 128 | 37 |
| – | Nick Kurtz ATH | 118 | 37 |
| – | Eugenio Suarez ARI | 110 | 37 |
| – | George Springer TOR | 158 | 37 |
| 17 | Riley Greene DET | 166 | 36 |
| 18 | Trent Grisham NYY | 153 | 34 |
| 19 | Jazz Chisholm Jr. NYY | 140 | 33 |
| – | Hunter Goodman COL | 145 | 33 |
| 21 | Salvador Perez KC | 156 | 32 |
| – | Vinnie Pasquantino KC | 159 | 32 |
| – | Shea Langeliers ATH | 127 | 32 |
| – | Brent Rooker ATH | 165 | 32 |
| – | Brandon Lowe TB | 138 | 32 |
| 26 | Corbin Carroll ARI | 148 | 31 |
| – | Teoscar Hernandez LAD | 152 | 31 |
| – | Cody Bellinger NYY | 162 | 31 |
| – | Pete Crow-Armstrong CHC | 165 | 31 |
| – | Vladimir Guerrero Jr. TOR | 175 | 31 |
| – | Francisco Lindor NYM | 161 | 31 |
| 32 | James Wood WSH | 158 | 30 |
| – | Randy Arozarena SEA | 175 | 30 |
| – | Jorge Polanco SEA | 153 | 30 |
| – | Spencer Torkelson DET | 162 | 30 |
| – | Willy Adames SF | 164 | 30 |
| 37 | Manny Machado SD | 165 | 29 |
| – | Ketel Marte ARI | 130 | 29 |
| – | Matt Olson ATL | 165 | 29 |
| – | Jose Ramirez CLE | 158 | 29 |
| 41 | Kerry Carpenter DET | 140 | 28 |
| – | Christian Yelich MIL | 160 | 28 |
| – | Kyle Manzardo CLE | 145 | 28 |
| 44 | Bryce Harper PHI | 138 | 27 |
| – | Ben Rice NYY | 148 | 27 |
| – | Mike Trout LAA | 135 | 27 |
| – | Andy Pages LAD | 173 | 27 |
| – | Christian Walker HOU | 154 | 27 |
| 49 | Freddie Freeman LAD | 167 | 26 |
| – | Brandon Nimmo NYM | 156 | 26 |
| – | Zach Neto LAA | 128 | 26 |
| – | Trevor Story BOS | 160 | 26 |
| – | Jose Altuve HOU | 157 | 26 |
| 54 | Fernando Tatis Jr. SD | 161 | 25 |
| – | Ian Happ CHC | 158 | 25 |
| – | Yandy Diaz TB | 153 | 25 |
| – | Tyler Soderstrom ATH | 162 | 25 |
| – | Kyle Stowers MIA | 120 | 25 |
| 59 | Mickey Moniak COL | 133 | 24 |
| – | Jackson Chourio MIL | 142 | 24 |
| – | Austin Wells NYY | 136 | 24 |
| – | Giancarlo Stanton NYY | 84 | 24 |
| – | Dansby Swanson CHC | 167 | 24 |
| – | Addison Barger TOR | 152 | 24 |
| 65 | Elly De La Cruz CIN | 167 | 23 |
| – | Marcell Ozuna ATL | 149 | 23 |
| – | Kyle Tucker CHC | 145 | 23 |
| – | Max Muncy LAD | 118 | 23 |
| – | Daulton Varsho TOR | 92 | 23 |
| – | Bobby Witt Jr. KC | 158 | 23 |
| – | Wyatt Langford TEX | 139 | 23 |
| – | Matt Chapman SF | 132 | 23 |
| 73 | Corey Seager TEX | 104 | 22 |
| – | Heliot Ramos SF | 161 | 22 |
| – | Josh Bell WSH | 141 | 22 |
| – | Spencer Steer CIN | 149 | 22 |
| – | Matt Wallner MIN | 108 | 22 |
| – | Lenyn Sosa CHW | 142 | 22 |
| 79 | Wilyer Abreu BOS | 118 | 21 |
| – | Ronald Acuna Jr. ATL | 93 | 21 |
| – | Colson Montgomery CHW | 70 | 21 |
| – | Alejandro Kirk TOR | 150 | 21 |
| – | Lawrence Butler ATH | 155 | 21 |
| – | Anthony Volpe NYY | 163 | 21 |
| – | Agustin Ramirez MIA | 135 | 21 |
| 86 | Andrew Benintendi CHW | 117 | 20 |
| – | Mookie Betts LAD | 168 | 20 |
| – | Brett Baty NYM | 132 | 20 |
| – | Yainer Diaz HOU | 145 | 20 |
| – | Geraldo Perdomo ARI | 165 | 20 |
| – | Lourdes Gurriel Jr. ARI | 133 | 20 |
| – | Oneil Cruz PIT | 137 | 20 |
| – | Adolis Garcia TEX | 140 | 20 |
| – | Isaac Paredes HOU | 104 | 20 |
| – | Will Smith LAD | 125 | 20 |
| – | Rafael Devers SF | 90 | 20 |
| 97 | Brice Turang MIL | 164 | 19 |
| – | Gavin Sheets SD | 152 | 19 |
| – | Kody Clemens MIN | 111 | 19 |
| – | CJ Abrams WSH | 145 | 19 |
| – | Michael Harris II ATL | 163 | 19 |
| – | Logan O'Hoppe LAA | 122 | 19 |
| – | Bo Bichette TOR | 147 | 19 |
| – | Willson Contreras STL | 131 | 19 |
| – | Drake Baldwin ATL | 125 | 19 |
| – | William Contreras MIL | 159 | 19 |
| 107 | Alec Burleson STL | 135 | 18 |
| – | Trevor Larnach MIN | 145 | 18 |
| – | Jackson Merrill SD | 121 | 18 |
| – | Alex Bregman BOS | 118 | 18 |
| – | Max Kepler PHI | 133 | 18 |
| – | Ivan Herrera STL | 107 | 18 |
| – | Jeremy Pena HOU | 127 | 18 |
| – | Carson Kelly CHC | 120 | 18 |
| 115 | Ozzie Albies ATL | 160 | 17 |
| – | Mark Vientos NYM | 123 | 17 |
| – | Miguel Vargas CHW | 140 | 17 |
| – | Jordan Westburg BAL | 85 | 17 |
| – | Nick Castellanos PHI | 151 | 17 |
| – | Jake Burger TEX | 108 | 17 |
| – | Jordan Beck COL | 152 | 17 |
| – | Jackson Holliday BAL | 148 | 17 |
| – | Gleyber Torres DET | 153 | 17 |
| 124 | Marcus Semien TEX | 131 | 16 |
| – | Bryan Reynolds PIT | 157 | 16 |
| – | Eugenio Suarez SEA | 65 | 16 |
| – | Ceddanne Rafaela BOS | 159 | 16 |
| – | Nathaniel Lowe WSH | 118 | 16 |
| – | Ryan McMahon COL | 101 | 16 |
| – | Sean Murphy ATL | 95 | 16 |
| – | Austin Hays CIN | 109 | 16 |
| – | Luis Garcia Jr. WSH | 140 | 16 |
| – | Wilmer Flores SF | 129 | 16 |
| – | Austin Riley ATL | 107 | 16 |
| – | Colton Cowser BAL | 93 | 16 |
| 136 | Trea Turner PHI | 146 | 15 |
| – | Matt McLain CIN | 152 | 15 |
| – | Luis Robert Jr. CHW | 112 | 15 |
| – | Maikel Garcia KC | 160 | 15 |
| – | Cedric Mullins BAL | 91 | 15 |
| – | Otto Lopez MIA | 146 | 15 |
| – | Jonathan Aranda TB | 110 | 15 |
| – | JJ Bleday ATH | 102 | 15 |
| – | Carlos Narvaez BOS | 123 | 15 |
| – | Ramon Laureano BAL | 82 | 15 |
| – | Brooks Lee MIN | 138 | 15 |
| – | Bo Naylor CLE | 130 | 15 |
| – | Jarren Duran BOS | 160 | 15 |
| – | Brenton Doyle COL | 140 | 15 |
| 150 | Dillon Dingler DET | 138 | 14 |
| – | Noelvi Marte CIN | 92 | 14 |
| – | Bryson Stott PHI | 152 | 14 |
| – | Gunnar Henderson BAL | 149 | 14 |
| – | Tommy Edman LAD | 114 | 14 |
| – | Nolan Gorman STL | 108 | 14 |
| – | TJ Friedl CIN | 157 | 14 |
| – | Michael Toglia COL | 89 | 14 |
| – | Josh Jung TEX | 133 | 14 |
| 159 | Royce Lewis MIN | 104 | 13 |
| – | J.T. Realmuto PHI | 141 | 13 |
| – | Matt Shaw CHC | 134 | 13 |
| – | J.P. Crawford SEA | 173 | 13 |
| – | Jorge Soler LAA | 87 | 13 |
| – | Ryan O'Hearn BAL | 93 | 13 |
| – | Jurickson Profar ATL | 84 | 13 |
| – | Andrew McCutchen PIT | 136 | 13 |
| – | Jacob Wilson ATH | 129 | 13 |
| – | Colt Keith DET | 143 | 13 |
| – | Javier Baez DET | 137 | 13 |
| – | Tyler Stephenson CIN | 91 | 13 |
| – | Rafael Devers BOS | 72 | 13 |
| – | Wenceel Perez DET | 106 | 13 |
| 173 | Eli White ATL | 110 | 12 |
| – | Brooks Baldwin CHW | 107 | 12 |
| – | Zach McKinstry DET | 153 | 12 |
| – | Jeff McNeil NYM | 120 | 12 |
| – | Josh Naylor SEA | 66 | 12 |
| – | Nathan Lukes TOR | 153 | 12 |
| – | Gabriel Arias CLE | 132 | 12 |
| – | Victor Caratini HOU | 116 | 12 |
| – | Michael Conforto LAD | 139 | 12 |
| – | Nolan Schanuel LAA | 137 | 12 |
| – | Nolan Arenado STL | 104 | 12 |
| – | Harrison Bader MIN | 100 | 12 |
| – | Casey Schmitt SF | 95 | 12 |
| – | Davis Schneider TOR | 91 | 12 |
| – | Will Benson CIN | 91 | 12 |
| – | Lars Nootbaar STL | 131 | 12 |
| – | Edmundo Sosa PHI | 95 | 12 |
| – | Yoan Moncada LAA | 84 | 12 |
| – | Rhys Hoskins MIL | 94 | 12 |
| 192 | Jake Cronenworth SD | 141 | 11 |
| – | Alec Bohm PHI | 126 | 11 |
| – | Josh Lowe TB | 112 | 11 |
| – | Coby Mayo BAL | 84 | 11 |
| – | Pedro Pages STL | 111 | 11 |
| – | Danny Jansen TB | 73 | 11 |
| – | Josh Naylor ARI | 97 | 11 |
| – | Christopher Morel TB | 109 | 11 |
| – | Joc Pederson TEX | 100 | 11 |